Fig. 6: LDTGo active center. | Nature Communications

Fig. 6: LDTGo active center.

From: A distinctive family of L,D-transpeptidases catalyzing L-Ala-mDAP crosslinks in Alpha- and Betaproteobacteria

Fig. 6: LDTGo active center.The alternative text for this image may have been generated using AI.

Electrostatic surface representation, ranging from –13.35 to +15.88 for YcbBEc (A), and from –15.69 to +12.77 for LDTGo (C) and ribbon diagram (B, D) of the donor and acceptor sites of YcbBEc in complex with the antibiotic meropenem (in yellow) (A, B) and of LDTGo (C, D). The dimensions of the donor and acceptor cavities as well as the positions of the relevant loops and residues are indicated. E LDTGo with the disaccharide tetrapeptide (M4) modeled in the active site. Molecular surface of LDTGo (green) with the catalytic C264 highlighted in yellow. The muropeptide is represented as sticks (C atoms colored in dark red). The positions of the relevant loops are indicated by arrows and labeled. F Detailed view of the interaction of the M4 muropeptide into the LDTGo active site. Relevant residues in the protein are represented as sticks and labeled.

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