Fig. 3: Large Aβ Agg [+] MCI patients display lower AD-like brain pathology than large Aβ Agg [-] MCI.
From: Amyloid-β aggregates activate peripheral monocytes in mild cognitive impairment
![Fig. 3: Large Aβ Agg [+] MCI patients display lower AD-like brain pathology than large Aβ Agg [-] MCI.](http://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41467-024-45627-y/MediaObjects/41467_2024_45627_Fig3_HTML.png?as=webp)
a 18F-FTP PET uptake in each group at baseline, two-year follow-up, and longitudinal change. The mean was calculated in a ROI comprising the entorhinal, amygdala, parahippocampal, fusiform, inferior temporal, and middle temporal cortical regions; mean ± SD. b Mean 11C-PiB PET uptake in each group at baseline, two-year follow-up, and longitudinal change. The mean uptake was calculated in a ROI comprising the prefrontal, orbitofrontal, anterior and posterior cingulate, precuneus, parietal, and temporal cortical regions; mean ± SD. c Mean cortical 18F-FTP PET uptake in each group at two-year follow-up (left panel) and statistical results from a two-sided unpaired t-test between large Aβ Agg [+] MCI patients vs. controls and large Aβ Agg [-] MCI patients, respectively (right panel). d Mean cortical 11C-PiB PET uptake in each group at two-year follow-up (left panel) and statistical results from a two-sided unpaired t-test between large Aβ Agg [+] MCI patients vs. controls and large Aβ Agg [−] MCI patients, respectively (right panel). Positive t-values (red) indicate significantly lower uptake in the large Aβ Agg [+] MCI group. Statistical cortical maps were familywise error rate corrected (α = 0.05) using cluster-extent-based thresholding with a primary cluster-defining threshold of p < 0.05. Source data are provided as a Source Data file.
