Fig. 7: p53 is associated with weight loss retention in obese humans. | Nature Communications

Fig. 7: p53 is associated with weight loss retention in obese humans.

From: Adipocyte p53 coordinates the response to intermittent fasting by regulating adipose tissue immune cell landscape

Fig. 7

a Plasma IL-6 levels before and after three cycles of fasting-mimicking diet (FMD) in a cohort of diabetic patients (n = 8). b–d Fat mass loss (in percent from baseline), plasma triglycerides, and HbA1c after FMD and stratification according to the TP53 P72R polymorphism (R72, n = 14 patients; P72, n = 6 patients). e–h Body mass index (BMI) regain, plasma triglycerides, HbA1c, and glucose in the same cohort (R72, n = 14 patients; P72, n = 6 patients) after 1 week of refeeding after three FMD cycles. i, j RNA-seq expression of TP53 (i) and the LAM marker TREM2 (j) in visceral AT from obese subjects that were collected at the time they underwent bariatric surgery and after follow-up of 2 years. Comparison between weight loss retainers (BMI ≥ 25% loss retained, n = 44 patients) and weight re-gainers (BMI < 25% loss retained, n = 36 patients). Data are presented as mean values ± SEM. Significant differences were analysed by two-tailed, paired (a, i, j) or unpaired (b–h) t-test. Exact p values are given in figures. Source data are provided as a Source Data file.

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