Fig. 8: Scheme of key findings. | Nature Communications

Fig. 8: Scheme of key findings.

From: Adipocyte p53 coordinates the response to intermittent fasting by regulating adipose tissue immune cell landscape

Fig. 8: Scheme of key findings.The alternative text for this image may have been generated using AI.

In the context of obesity, intermittent fasting increases the abundance of lipid-associated macrophages (LAMs) in crown-like structures of visceral adipose tissue of mice. This coincides with adipocyte apoptosis and activation of p53 signalling. Knock out (KO) of p53 specifically in adipocytes reduces inflammatory and apoptotic signalling, while elevating the catabolic state of adipocytes. Consequently, p53 KO leads to increased weight loss, enhancing the metabolic health benefits of intermittent fasting. Data in human cohorts implicate p53 in clinical weight loss scenarios. Created with BioRender (www.biorender.com).

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