Fig. 7: A schematic illustration of the working model. | Nature Communications

Fig. 7: A schematic illustration of the working model.

From: MYC induces CDK4/6 inhibitors resistance by promoting pRB1 degradation

Fig. 7: A schematic illustration of the working model.The alternative text for this image may have been generated using AI.

MYC amplification drives CDK4/6i resistance by activating an E3 ligase KLHL42, which is responsible for pRB1 ubiquitination and degradation, and subsequently confers resistance to CDK4/6i. A MYC degrader A80.2HCl that can efficiently reduce MYC protein level protects pRB1 and overcomes CDK4/6i resistance. The combination of A80.2HCl and CDK4/6i sheds light on potentially strategies for cancer treatment.

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