Fig. 1: Overview of the nucleotide salvage pathway and kinetic model parameter sensitivities to observed species.
From: Iterative design of training data to control intricate enzymatic reaction networks
a Reaction scheme of the in vitro reconstructed part of the nucleotide salvage pathway. The network consists of 6 enzymes and 15 substrates/products, resulting in a set of ODEs containing over 40 kinetic parameters. b Positive and negative correlations between the forward sensitivities between the kinetic parameters with respect to the measured output.
