Fig. 5: Gene Set Variation Analysis (GSVA) of significant differentially enriched pathways in responders versus non-responders. | Nature Communications

Fig. 5: Gene Set Variation Analysis (GSVA) of significant differentially enriched pathways in responders versus non-responders.

From: Clinical and biomarker results from a phase II trial of combined cabozantinib and durvalumab in patients with chemotherapy-refractory colorectal cancer (CRC): CAMILLA CRC cohort

Fig. 5

The y-axis represents annotated gene sets from the Nanostring Cancer Transcriptome Atlas. The pathways are organized within modules of Cell Function, Metabolism, Immune Response, Innate and Adaptive Immunity and Signaling Pathways. The x-axis represents the fold change difference of differentially enriched pathways in responders in comparison to non-responders. Upregulated pathways are tinted in red and downregulated pathways are tinted in blue. A GSVA of tumor epithelial compartment showing significant differentially enriched pathways in responders. B GSVA of stroma compartment showing significant differentially enriched pathways in responders. Comparison between responders and non-responders was performed using a linear fit model from Limma with p-values corrected for multiple comparisons using BH method.

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