Fig. 7: T-cell inflamed gene expression signature (TIS) in responders versus non-responders.

A Heatmap of genes in T-cell inflamed gene expression signature representing the scaled expression of TIS genes. Patients are depicted by key (ID). B Boxplots showing differences in the TIS scores between responders and non-responders. The y-axis represents the TIS score. Statistical significance was tested using Wilcoxon’s rank sum test. Responders (R, n = 4), non-responders (NR, n = 16). Box and whisker plots show all data points with median as center line with 25th and 75th percentiles. Two-sided Wilcoxon (Mann–Whitney U) test was performed.