Table 3 Estimated associations between SDB PC metabolite risk scores and their respective phenotypes, in batch 1 and 2

From: Metabolomic profiles of sleep-disordered breathing are associated with hypertension and diabetes mellitus development

 

Both

Female

Male

 

n

Coef [95%CI]

p

n

Coef [95%CI]

p

n

Coef [95%CI]

p

Batch 1

SDB PC1 MRS

      

Model 1

3299

0.29 [0.24, 0.34]

2.03E-33

1874

0.31 [0.25, 0.36]

1.55E-27

1425

0.26 [0.19, 0.33]

1.44E-12

Model 2

3256

0.30 [0.25, 0.36]

4.75E-34

1854

0.31 [0.25, 0.36]

2.72E-28

1402

0.26 [0.19, 0.33]

9.72E-13

SDB PC2 MRS

      

Model 1

3299

0.23 [0.19, 0.28]

6.04E-22

1421

0.24 [0.17, 0.32]

7.71E-10

1425

0.23 [0.17, 0.28]

1.12E-14

Model 2

3256

0.23 [0.18, 0.28]

5.50E-22

1406

0.23 [0.15, 0.30]

1.20E-09

1402

0.22 [0.17, 0.28]

2.35E-15

Sex Specific SDB PC1 MRS

      

Model 1

   

1421

0.32 [0.26, 0.37]

1.94E-32

1425

0.32 [0.26, 0.38]

2.82E-26

Model 2

   

1406

0.32 [0.27, 0.37]

5.74E-35

1402

0.32 [0.26, 0.37]

8.50E-28

Sex Specific SDB PC2 MRS

      

Model 1

   

1421

0.13 [0.06, 0.19]

1.12E-04

1425

0.23 [0.17, 0.30]

2.77E-12

Model 2

   

1406

0.10 [0.04, 0.17]

1.70E-03

1402

0.22 [0.16, 0.29]

4.38E-12

Batch 2

SDB PC1 MRS

      

Model 1

1522

0.15 [0.08, 0.23]

1.18E-04

960

0.09 [0.01, 0.19]

6.26E-02

562

0.20 [0.10, 0.31]

1.37E-04

Model 2

1500

0.15 [0.07, 0.23]

2.29E-04

950

0.08 [−0.01, 0.17]

9.28E-02

552

0.20 [0.10, 0.30]

5.50E-05

SDB PC2 MRS

      

Model 1

1484

0.14 [0.05, 0.22]

1.54E-03

941

0.13 [0.01, 0.26]

3.72E-02

562

0.14 [0.05, 0.23]

2.22E-03

Model 2

1463

0.14 [0.06, 0.22]

4.57E-04

932

0.13 [0.02, 0.24]

2.50E-02

552

0.15 [0.05, 0.25]

2.32E-03

Sex Specific SDB PC1 MRS

      

Model 1

   

941

0.08 [0.00, 0.15]

4.53E-02

562

0.13 [0.04, 0.21]

2.21E-03

Model 2

   

932

0.07 [−0.01, 0.14]

7.52E-02

552

0.13 [0.04, 0.21]

2.63E-03

Sex Specific SDB PC2 MRS

      

Model 1

   

941

0.03 [−0.09, 0.14]

6.61E-01

562

0.12 [0.02, 0.22]

1.86E-02

Model 2

   

932

0.03 [−0.07, 0.13]

4.92E-01

552

0.13 [0.04, 0.22]

5.17E-03

  1. Coef: coefficients are estimates of the incident rate ratio per 1 SD increase in a metabolite risk score (MRS). p-values were derived from a two-sided, 1 degree-of-freedom Wald test. Bolded values in the p column indicate their values are below 0.05. Model 1 adjusted for demographic variables, including age, sex, field center, Hispanic/Latino background and body mass index (BMI); Model 2 adjusted for all model 1 covariates and lifestyle variables – alcohol use, cigarette use, total physical activity (MET-min/day), and diet (Alternative Healthy Eating Index 2010) in addition to demographic variables.
  2. SDB PC1 MRS/SDB PC2 MRS: metabolite risk scores developed based on coefficients from LASSO regression trained in both sex strata combined to predict the outcome (SDB PC1, or SDB PC2) in the discovery dataset (batch 1). Sex-specific SDB PC1 MRS/PC2 MRS: metabolite risk scores developed based on coefficients from LASSO regression trained in each sex stratum to predict the outcome (SDB PC1, or SDB PC2) in the discovery dataset (batch 1).
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