Fig. 4: Spatial patterns of association with structural connectivity.

For brevity, only the 12 most significant lead variants are shown; the remaining 18 are shown in Supplementary Fig. 1. Asterisks (*) indicate associations passing Bonferroni-corrected genome-wide significance (p < 5 × 10^–8 / 206 ≈ 2.4 × 10⁻¹⁰), while dots (·) indicate associations significant after Bonferroni correction for just the 30 variants times the number of measures (p < 0.05 / 30 / 206 ≈ 8.1 × 10^–6). Effect sizes (β) are oriented with respect to the minor allele, so positive effect sizes (red) indicate that the minor allele is associated with increased structural connectivity, while negative effect sizes (blue) indicate that the minor allele is associated with decreased connectivity. LH left-hemisphere, RH right-hemisphere, Vis visual, SomMot somatomotor, DorsAttn dorsal attention, SalVentAttn salience/ventral attention, Limbic limbic, Cont control, Default default mode.