Fig. 1: Modular and regio-/stereoselective synthesis of all-carbon tetrasubstituted olefins. | Nature Communications

Fig. 1: Modular and regio-/stereoselective synthesis of all-carbon tetrasubstituted olefins.

From: Remote-carbonyl-directed sequential Heck/isomerization/C(sp2)–H arylation of alkenes for modular synthesis of stereodefined tetrasubstituted olefins

Fig. 1

a Yoshida’s chelation-assisted regio-/stereoselective synthesis of tetra-arylated alkenes. b Studer’s sequential oxidative Heck arylation for the stereoselective synthesis of tetrasubstituted olefins. c Dong’s modular and regioselective synthesis of tetrasubstituted olefins enabled by an alkenyl Catellani reaction. d This work: native carbonyl group directed stereospecific sequential arylation of alkenes via a pivotal E/Z isomerization. Pd, palladium. Ar, aryl. DIBAL-H, Diisobutylalumium Hydride. E, electrophile. Nu, nucleophile. DG, directing group.

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