Fig. 3: Functional analysis of interactions between each Ece1 peptide and the human ORFeome.
From: Global fungal-host interactome mapping identifies host targets of candidalysin
a Histograms of GO enrichment analysis associated with each Ece1 peptide. The top significantly enriched features are shown by categories of Biological Processes, Cellular Components, and Molecular Functions. q-values are calculated using the Benjamini-Hochberg procedure. b Heatmap of feature enrichment analysis for the eight Ece1 peptides, for which the first 100 features (right side) were selected to plot the heatmap. It is colored by P-value, where darker colors indicate lower values (i.e., greater enrichment) and gray color indicates the peptide is not enriched for the associated feature. P-values were calculated based on the cumulative hypergeometric distribution. c Networks of GO enrichment analysis were inferred for features associated with each color-coded Ece1 peptide: I (red), II (blue), III (green), IV (purple), V (yellow), VI (missing), VII (pink), and VIII (missing). Each circle represents all the genes in the same pathway categorized by different peptides, and circles containing multiple colors indicate multiple peptides share the feature.
