Fig. 6: Proposed model of the IsmP-ImcA signaling switch in response to iron involved in regulation of P. aeruginosa behaviors.
From: A c-di-GMP signaling module controls responses to iron in Pseudomonas aeruginosa
Under iron-defective conditions, IsmP directly interacts with ImcA, which results in the inhibition of ImcA’s DGC activity and produces low intracellular c-di-GMP levels. Conversely, when under iron-rich conditions, CHASE4 senses iron to alleviate the inhibitory effect of IsmP on ImcA and thus stimulates the DGC activity of ImcA. The high concentrations of c-di-GMP tend to form cellular aggregation, wrinkly colony, and biofilm. Notably, GTP is also accumulated near the cell membrane in proximity to ImcA, which participates in the synthesis of c-di-GMP.
