Fig. 3: Overall architecture of niacin, acipimox, MK6892, GSK256073 and MMF bound GPR109A-G protein complexes. | Nature Communications

Fig. 3: Overall architecture of niacin, acipimox, MK6892, GSK256073 and MMF bound GPR109A-G protein complexes.

From: Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution

Fig. 3

Map and ribbon diagram of the ligand-bound GPR109A-Go complexes (front view) and the cryo-EM densities of the ligands (sticks) are depicted as transparent surface representations. a niacin-GPR109A-Go: Light coral: GPR109A, blue violet: miniGαo, rosy brown: Gβ1, chartreuse: Gɣ2, gray: ScFv16, b acipimox-GPR109A-Go: medium aquamarine: GPR109A, blue violet: miniGαo, rosy brown: Gβ1, chartreuse: Gɣ2, gray: ScFv16, c MK6892-GPR109A-Go: olive drab: GPR109A, blue violet: miniGαo, rosy brown: Gβ1, chartreuse: Gɣ2, gray: ScFv16, d GSK256073-GPR109A-Go: Steel blue: GPR109A, blue violet: miniGαo, rosy brown: Gβ1, chartreuse: Gɣ2, gray: ScFv16, e MMF-GPR109A-Go: Dark golden rod: GPR109A, blue violet: miniGαo, rosy brown: Gβ1, chartreuse: Gɣ2, gray: ScFv16.

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