Fig. 6: Major conformational changes on GPR109A activation. | Nature Communications

Fig. 6: Major conformational changes on GPR109A activation.

From: Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution

Fig. 6

a Superimposition of inactive GPR109A with receptor bound to niacin, acipimox, MK6892, GSK256073, and MMF. b, c Displacements of TM5, TM6 upon GPR109A activation in the structures of niacin, acipimox, MK6892, GSK256073, and MMF bound GPR109A respectively. d Conformational changes in the conserved microswitches (DRY, PIF, NPxxY, CW/FxP) in the active structure of GPR109A.

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