Table 4 Somatosensory evoked potentials for patients at baseline, 12 months, and 24 months after AD-MSC injection or right upper, left upper, right lower and left lower limbs at each evaluation
Patient # | Baseline SSEP | First SSEP after Injection | Final SSEP after Injection | Overall Interpretation |
|---|---|---|---|---|
Patient 1 | UE SSEP: Bilateral absolute scalp latencies prolonged. All bilateral interpeak latencies prolonged. LE SSEP: Bilateral absolute scalp latencies prolonged. Bilateral lumbar-to-scalp and left cervical-to-scalp interpeak latencies prolonged. | Performed at 5 months: UE SSEP: Bilateral absolute scalp latencies prolonged. Bilateral cervical-to-scalp and clavicle-to-scalp interpeak latencies prolonged. LE SSEP: Bilateral absolute scalp latencies prolonged. Bilateral lumbar-to-scalp interpeak latencies prolonged. | Performed at 18 months: UE SSEP: Bilateral absolute scalp and left absolute cervical latencies prolonged. Bilateral clavicle-to-scalp and left clavicle-to-cervical interpeak latencies prolonged. LE SSEP: Left absolute scalp latency prolonged. Left lumbar-to-scalp interpeak latency prolonged. | Mild improvement mainly in the right lower extremity SSEPs. |
Patient 2 | UE SSEP: Normal left median potentials and latencies. Right median SSEP not performed. LE SSEP: Absent left cervical and scalp potentials. Normal left absolute lumbar potential and latency. Right tibial SSEP not performed. | Performed at 9 months: UE SSEP: Not performed. LE SSEP: Absent left cervical and scalp potentials. Normal left absolute lumbar potential and latency. No response elicited on the right. | Performed at 19 months: UE SSEP: Not performed. LE SSEP: No reproducible peripheral or central potentials. | No reliable interpretation. |
Patient 3 | UE SSEP: Bilateral clavicle-to-scalp and clavicle-to-cervical interpeak latencies prolonged. LE SSEP: Normal. | Performed at 5 months: UE SSEP: Normal. LE SSEP: Normal. | Performed at 17 months: UE SSEP: Normal. LE SSEP: Normal. | Improvement in UE SSEP from abnormal at baseline to normal at 5 months. |
Patient 4 | UE SSEP: Normal. LE SSEP: Normal. | Performed at 5 months: UE SSEP: Normal. LE SSEP: Normal. | Performed at 15 months: UE SSEP: Not performed. LE SSEP: Normal. | Normal throughout. |
Patient 5 | UE SSEP: Not performed. LE SSEP: Bilateral absolute scalp potentials mildly prolonged. Left lumbar-to-scalp interpeak latency borderline prolonged. | Performed at 5 months: UE SSEP: Not performed. LE SSEP: No reliable information obtained. | Performed at 17 months: UE SSEP: Not performed. LE SSEP: Normal bilateral absolute lumbar potentials. No other reliable information obtained. | No reliable interpretation. |
Patient 6 | UE SSEP: Right clavicle-to-cervical and left clavicle-to-scalp interpeak latency mildly prolonged. LE SSEP: Normal bilateral lumbar potentials. Normal left cervical absolute and lumbar-to-cervical interpeak latency. No other reliable information obtained. | Performed at 5 months: UE SSEP: Left clavicle-to-scalp interpeak latency borderline prolonged. Normal right absolute and interpeak latencies. LE SSEP: Normal left cervical and bilateral lumbar absolute latencies. Normal lumbar-to-cervical interpeak latency. No other reliable information obtained. | Performed at 17 months: UE SSEP: Left clavicle-to-scalp interpeak latency borderline prolonged. Normal right absolute and interpeak latencies. LE SSEP: Normal bilateral lumbar potentials. No other reliable information obtained. | No significant change from baseline. |
Patient 7 | UE SSEP: Normal. LE SSEP: No reliable information obtained. | Performed at 7 months: UE SSEP: Not performed. LE SSEP: Normal bilateral lumbar absolute latencies. No other reliable information obtained. | Performed at 17 months: UE SSEP: Not performed. LE SSEP: Normal bilateral absolute lumbar latencies. Right absolute scalp and lumbar-to-scalp interpeak latencies prolonged. | No reliable interpretation. |
Patient 8 | UE SSEP: Left cervical and scalp absolute latencies prolonged. All left interpeak latencies prolonged. Right clavicle-to-scalp interpeak latency prolonged. LE SSEP: No reliable information obtained. | Performed at 11 months: UE SSEP: Bilateral clavicle-to-cervical and clavicle-to-scalp interpeak latencies prolonged. LE SSEP: No reliable information obtained. | Performed at 16 months: UE SSEP: Bilateral clavicle-to-scalp interpeak latencies prolonged. Right clavicle-to-cervical interpeak latency prolonged. LE SSEP: Normal left cervical and right lumbar absolute latencies. No other reliable information obtained. | No change from baseline. |
Patient 9 | UE SSEP: Bilateral clavicle-to-scalp and right clavicle-to-cervical interpeak latencies prolonged. LE SSEP: Bilateral lumbar-to-scalp interpeak latency prolonged. | Performed at 7 months: UE SSEP: Normal. LE SSEP: Left absolute scalp latency normal. No other reliable information obtained. | Performed at 15 months: UE SSEP: Normal. LE SSEP: Normal bilateral absolute scalp latencies. No other reliable information obtained. | Resolution of upper extremity central potential prolongation. No reliable interpretation for lower extremities. |
Patient 10 | UE SSEP: Normal right absolute clavicle latency. No other reliable information obtained LE SSEP: No reliable information obtained. | NA | NA | No reliable interpretation. |
