Fig. 6: Alteration of PSD proteome at late developmental stage in marmoset neocortex.
From: Remodeling of the postsynaptic proteome in male mice and marmosets during synapse development
a Schematic diagram of the trajectory of synapse density in marmoset neocortex reported previously7. b Log10 fold change of the abundance of proteins in DDP-MH and DIP-MH groups in the developmental mouse cortex (12 week-old vs. 2 week-old) plotted against that of marmoset neocortex at neonatal period (12 month-old vs 2 month-old). c Log10 fold change of protein abundance in the developmental marmoset neocortex (2-month-old vs. 0 month-old) plotted against that at a later period (24 month-old vs. 2 month-old). d Hypothetical model illustrating the trajectory of PSD composition in primate and rodent brains. Phase 1 changes include a decrease of DDP and an increase of DIP and take place at later postnatal development in rodent brain and perinatal-neonatal period in mouse brain. Phase 2 changes include a decrease of Late-DDP and an increase of Late-DIP, taking place at later postnatal development in primate brains. In this period, Phase 1 change also continued to a lower extent. e Expression profile of the proteins which showed more than a 2-fold decrease (termed ‘late DDP’) or increase (termed ‘Late DIP’) in marmoset brain from 2 month-old to 24 month-old. Black lines indicate the average. f Canonical pathway analysis using IPA. Pathways with the top 10 lowest raw P-values were shown. (left) Enrichment of indicated terms in DDP and DIP described as P-value (right) Percentage of proteins included in each term. g and h Venn diagram illustrating the overlap of the proteins classified into DDP, DIP, Late DDP, and Late DIP. Total proteins (g) or proteins of Synaptogenesis Signaling Pathways (h) are described. Source data are provided as a Source Data file.
