Table 3 Prevalence of Plasmodium falciparum drug resistance markers among first antenatal care users and children

From: Genomic malaria surveillance of antenatal care users detects reduced transmission following elimination interventions in Mozambique

 

All

First ANC

Children

Gene

Haplotype/marker

n/N (%)

n/N (%)

n/N (%)

p

pfk13

 

446-458-476-493

0/343 (0.0%)

0/260 (0.0%)

0/83 (0.0%)

1.00

 

539-543-553-561-574-580

0/341 (0.0%)

0/258 (0.0%)

0/83 (0.0%)

1.00

pfdhps

 

I431V

0/374 (0.0%)

0/284 (0%)

0/90 (0.0%)

1.00

 

A437G

351/365 (96.2%)

266/276 (96.4%)

85/89 (95.5%)

0.96

 

K540E

335/355 (94.4%)

256/269 (95.2%)

79/86 (91.9%)

0.37

 

A581G

0/372 (0.0%)

0/283 (0.0%)

0/89 (0.0%)

1.00

 

double 437-540

285/300 (95.0%)

220/231 (95.2%)

65/69 (94.2%)

0.75

pfdhfr

 

N51I

349/352 (99.1%)

261/264 (98.9%)

88/88 (100%)

0.58

 

C59R

333/337 (98.8%)

247/251 (98.4%)

86/86 (100%)

0.58

 

S108N

350/353 (99.2%)

265/268 (98.9%)

85/85 (100%)

1.00

 

triple 51-59-108

282/286 (98.6%)

210/214 (98.1%)

72/72 (100%)

0.58

pfdhps-pfdhfr

 

quíntuple 51-59-108-437-540

233/245 (95.1%)

179/187 (95.7%)

54/58 (93.1%)

0.49

pfmdr1

 

N86Y

4/335 (1.2%)

3/255 (1.2%)

1/80 (1.3%)

1.00

 

F184Y

251/333 (75.4%)

194/252 (77.0%)

57/81 (70.1%)

0.38

 

D1246Y

1/377 (0.3%)

1/287 (0.3%)

0/90 (0.0%)

1.00

pfcrt

 

72-76 CVIET

4/357 (1.1%)

1/273 (0.4%)

3/84 (3.6%)

0.042

  1. n number of individuals carrying a mutant allele, N total individuals with a valid call. In individuals carrying multiple different genotypes at a given locus, both alleles are considered valid if eMOI>1.1, otherwise only the major allele is included. p values from Pearson’s chi-square test or Fisher exact test of difference in proportion between ANC and children, depending on sample size.
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