Fig. 3: Comparison of in vitro and in vivo approaches for enzyme optimization. | Nature Communications

Fig. 3: Comparison of in vitro and in vivo approaches for enzyme optimization.

From: Automated in vivo enzyme engineering accelerates biocatalyst optimization

Fig. 3

The figure shows and scores the properties of the two methods for several key performance indicators (KPIs). Moreover, the use of additional technical improvements to the approaches is included, such as random mutagenesis (RM), directed evolution (DE), hypermutators and adaptive laboratory evolution (ALE). The impact of these improvements on the KPIs is also depicted in the figure.

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