Fig. 2: Substrate scope for synthesis of meta-carbonyl phenols. | Nature Communications

Fig. 2: Substrate scope for synthesis of meta-carbonyl phenols.

From: Synthesis of meta-carbonyl phenols and anilines

Fig. 2

a Substrate scope of aryl ketones. b Substrate scope of conjugated enones. c Substrate scope of aliphatic ketones and aldehydes. Reaction conditions: substrate (0.25 mmol), CuI (10 mol%), AgOAc (9 mol%), and TFA (10.0 equiv) in DMSO (1 mL), H2O (50 μL) under O2 at 90 oC for 60 h. Isolated yields are reported. aReaction conducted with 1a (5.5 mmol). bAgOAc (9.5 mol%) was used. c48 h. d100 oC. eNo addition of H2O. fPd(OAc)2 (15 mol%) was used instead of AgOAc.

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