Fig. 3: Substrate scope for synthesis of meta-carbonyl anilines.

a Substrate scope of anilines. b Substrate scope of aromatic ketones. c Substrate scope of N-acetyl anilines. d Substrate of N-propionyl aniline. e Substrate of N-tert-butoxycarbonyl aniline. Reaction conditions: 1 (0.25 mmol), 11 (0.5 mmol) or 14 (0.5 mmol) or 15 (0.5 mmol), CuI (10 mol%), TBHP (2.2 equiv), and TFA (10.0 equiv) in DMSO (1 mL) at 90 ^oC for 60 h. Isolated yields are reported. ^aTBHP (1.1 equiv). ^bTBHP (2.0 equiv). ^c36 h. ^dAgOAc (9 mol%) instead of TBHP. Boc, tert-butoxycarbonyl.