Fig. 5: Single-cell transcriptome sequencing was used to characterize cellular and molecular changes in innate immune cells. | Nature Communications

Fig. 5: Single-cell transcriptome sequencing was used to characterize cellular and molecular changes in innate immune cells.

From: Long-term effects of Omicron BA.2 breakthrough infection on immunity-metabolism balance: a 6-month prospective study

Fig. 5: Single-cell transcriptome sequencing was used to characterize cellular and molecular changes in innate immune cells.

a UMAP graph visualizes type and clustering of innate immune cells. b Violin diagram showing the expression level of NK cell effector proteins in the control and BA.2-BTI-6m groups. P values are calculated by the two tailed Wilcoxon rank sum test, ****p < 0.0001, ns p > 0.05. c Volcanic map showing differentially expressed genes in NK cells in both groups. d Bubble chart displaying biological functions enriched by differentially expressed genes in NK cells. e UMAP plot showing subpopulations of CD14 monocytes. f UMAP plot showing the expression level of MS1 cell gene marker. g Volcanic map showing differentially expressed genes in MS1 cells in both groups. h Bubble chart displaying biological functions enriched by differentially expressed genes in MS1 cells. P value is calculated through hypergeometric testing and adjusted by the Benjamin and Hochberg methods. i Box plot showing differences in protein processing, and antigen-presenting activity scores of innate immune cells. Minima: Lower limit of the whisker; Maxima: Upper limit of the whisker; Centre: Median line inside the box; The upper and lower box bounds represent the 25% and 75% percentile of data. Two tailed Wilcoxon rank sum test.

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