Fig. 1: Overview of TreeAlign. | Nature Communications

Fig. 1: Overview of TreeAlign.

From: Allele-specific transcriptional effects of subclonal copy number alterations enable genotype-phenotype mapping in cancer cells

Fig. 1: Overview of TreeAlign.

a TreeAlign takes raw count data from scRNA-seq, the copy number matrix and the phylogenetic tree from scDNA-seq. By recursively assigning the expression profiles to phylogenetic subtrees, TreeAlign infers the clone-of-origin of cells identified in scRNA-seq and the dosage effects of subclonal CNAs. b Allelic imbalance can be inferred from DNA data and RNA data. We assume a positive correlation between the two measurements to improve clone assignment. c Graphical model of TreeAlign.

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