Fig. 1: Comparison of the two types of ligature models and temporal mRNA expression profiling of cytokines.
From: The IL-33/ST2 axis is protective against acute inflammation during the course of periodontitis
a Representative maxillary μCT images. Scale bar, 1 mm. b Temporal change of bone loss on different tooth regions. From left to right: the first molar, the second molar, the third molar, and their sum (n = 4 mice per group). c Representative TRAP staining images. Scale bar, 300 μm. d mRNA expression of Il6 and the Tnfsf11/Tnfrsf11b ratio on the control side of the three tissues (on Day 1; GT = 1; n = 4 mice per group except for the group highlighted in Source Data file, which was n = 3 mice). e Temporal changes in mRNA expression of Il6 and the Tnfsf11/Tnfrsf11b ratio in the three tissues (control Day 1 of each tissue = 1; n = 4 mice per group except for the groups highlighted in Source Data file, which were n = 3 mice per group). GT gingival tissue, PRT peri-root tissue, BT bone tissue, D1 Day 1, D3 Day 3, D5 Day 5, D8 Day 8, D14 Day 14. Data are presented as the mean ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001; ns (not significant), P > 0.05; by one-way ANOVA with multiple comparisons via Tukey’s test (d); and two-way ANOVA with multiple comparisons via Šídák’s method (b, e). The obvious outliers were evaluated and excluded by Grubb’s test (α = 0.05). Exact P values are presented in Supplementary Data. 1. Source data are provided as a Source Data file.
