Fig. 7: Schematic illustration of inflammatory gene expression profiles in the course of periodontitis and the role of the IL-33/ST2 axis against acute inflammation.
From: The IL-33/ST2 axis is protective against acute inflammation during the course of periodontitis
a Visualization of the mRNA expression of key cytokines throughout the pathogenetic process of periodontitis in the three tissues. The scale of the cytokine circles is based on the minimum expression tissue on the control side on day 1. The size ratio of the circles in the normal part is disproportionate to the subsequent parts to show the expression differences between the tissues more clearly. b Visualization of the possible mechanism of the pathogenesis in IP and the possible working mechanism of the IL-33/ST2 axis. The diagram was divided by dot line into two parts: the left side represents the normal situation, and the right side represents the Il33- or Il1rl1-deficient situation. mST2 membrane form of ST2, sST2 soluble form of ST2, GT gingival tissue, PRT peri-root tissue, BT bone tissue.
