Fig. 2: Two PIP2 binding sites at the interface of Kir6.2 and SUR1. | Nature Communications

Fig. 2: Two PIP2 binding sites at the interface of Kir6.2 and SUR1.

From: Structure of an open KATP channel reveals tandem PIP2 binding sites mediating the Kir6.2 and SUR1 regulatory interface

Fig. 2

a CryoEM map features of two PIP2 molecules colored in cyan and magenta (0.08 V, 4.0σ contour), respectively. b Structural model of the PIP2 binding pocket (red boxed region in (a)) viewed from the side, with cryoEM density of PIP2 shown as gray mesh. Residues from both Kir6.2 (adjacent subunit denoted “B”) and SUR1 (gray outline) surrounding bound PIP2 molecules are labeled. c Structural model of the PIP2 binding pocket view from the top (extracellular side).

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