Fig. 4: Analysis of differentially expressed genes among the yeast-form strain and evolved aggregative isolates of C. auris.
From: Rapid evolution of an adaptive multicellular morphology of Candida auris during systemic infection
Strains analyzed: BJCA001 (yeast-form), CHS1 p.Q826* (chs1, FDAG4), BNI1 p.206 fs (bni1, FDAG30), LRG1 p.K427* (lrg1, FDAG9), and CAS4 p.1288 fs (cas4, FDAG1). a Hierarchical clustering of differentially expressed genes (DEGs) between different strains using Euclidean distance. b Numbers of DEGs associated with CWI, cytoskeleton, and cell cycle/cytokinesis regulation between the yeast-form strain and CHS1 p.Q826*, BNI1 p.206 fs, LRG1 p.K427*, or CAS4 p.1288 fs mutants. c Venn plot of DEGs between the yeast-form strain and BNI1 p.206 fs, LRG1 p.K427*, or CAS4 p.1288 fs mutants. d Representative common DEGs among the CHS1 p.Q826*, BNI1 p.206 fs, LRG1 p.K427*, and CAS4 p.1288 fs mutants. e Representative common DEGs among the BNI1 p.206 fs, LRG1 p.K427*, and CAS4 p.1288 fs mutants. f Representative common DEGs between the LRG1 p.K427* and CAS4 p.1288 fs mutants. Log2 (fold change) values of DEGs between the yeast-form strain and corresponding mutant strains are shown in (d)–(f).
