Fig. 2: Development of a palladium-catalysed electrocarboxylation method.
From: Efficient palladium-catalyzed electrocarboxylation enables late-stage carbon isotope labelling
a Key steps involved in the CRC of aryl electrophiles. b Selected optimisation results. Unless otherwise noted, all reactions were performed in an H-cell with 0.4 mmol of aryl electrophile (1 equiv.) and 3 mL of DMF in each chamber (see SI Section 2). c The reaction setup. d Performing published CRC methods with 1.5 equivalents of CO2 in the two-chamber (see SI Section 3)16,17,19,23,25,27. aYields were obtained by 1H NMR spectroscopy of a crude reaction mixture with an internal standard.
