Fig. 1: CEPsh glia grow congruently with muscle and epithelia, to envelop axons and synapses. | Nature Communications

Fig. 1: CEPsh glia grow congruently with muscle and epithelia, to envelop axons and synapses.

From: Age-progressive interplay of HSP-proteostasis, ECM-cell junctions and biomechanics ensures C. elegans astroglial architecture

Fig. 1

a, b Wild-type CEPsh glia grow throughout larval and adult stages, expanding their membrane volume (b). n = 14 animals per stage. Primary data are presented in the provided Source Data file. CEPsh glia, in L4 animals, appose to epidermis (c), muscle (d), and envelop brain-neuropil axons (e) such as the AIY axon (f) and can associate closely with RAB-3-labeled presynaptic sites (here of the AIY neuron) (a–h) (CEPsh; green, others pseudocolored magenta). Cross-sectional views in c(iv)-h(iv), models in c(v)-h(v). Reporters as listed in “Methods”, Supplementary Tables 1 and 3. Scale bars, 10 μm. D dorsal, V ventral, A anterior, P posterior (also see Supplementary Movies 1–3). In box-whisker plots, the dots, center lines, X symbols, box limits, whiskers represent respectively individual values, means, 25th and 75th percentiles, maximum and minimum values.

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