Fig. 1: Malformations in the E16.5 Tgfbr1-cKO fetuses. | Nature Communications

Fig. 1: Malformations in the E16.5 Tgfbr1-cKO fetuses.

From: Tgfbr1 controls developmental plasticity between the hindlimb and external genitalia by remodeling their regulatory landscape

Fig. 1: Malformations in the E16.5 Tgfbr1-cKO fetuses.The alternative text for this image may have been generated using AI.

Images of fixed control (A) and Tgfbr1-cKO (B) fetuses. The mutant fetus shows the presence of an omphalocele (asterisk) and hindlimb duplication. C 3D reconstruction of the limb skeleton of a Tgfbr1-cKO fetus obtained by OPT and after segmentation of the limb skeleton. Extra hindlimbs are in magenta. Ossification shown in yellow. D–E’ 3D reconstruction of organs and the excretory outlets of the control (D, D’) and Tgfbr1-cKO (E, E’) fetuses. Images were obtained by OPT, followed by segmentation of the relevant structures. D’ E’ show virtual sections of the segmented 3D specimen. Asterisk in E’ shows the gut-bladder connection in the mutant. K kidney, G gut, Bl bladder, Ov ovary, Ut uterus, V vagina, Ur urethra.

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