Fig. 4: Analysis of trials with statistical comparisons of side effects (SE).
From: Outcome differences by sex in oncology clinical trials
a The numbers of trials with a multivariate or univariate comparison of side effects between males and females. lesser SE in Males means here that the side effect is statistically less common or less severe in males. b Counts of the trials in panel a for the five malignancies with the most comparisons - FDR for Colorectal cancer is not far from significant, P = 0.07. For each malignancy, a two-sided binomial test was used to determine whether the proportion of male-favoring (blue) to female-favoring (pink) trials was significantly different from 1:1. P-values were corrected for multiple hypothesis testing using the Benjamini–Hochberg method. Significant FDR values are displayed in the figure. All others are available in Supplementary Tables. Source data are provided as a Source Data file.
