Table 1 After completing an initial attempt to find trials with sex differences based on an April 2022 data freeze, we carried out various quality control tests (Methods)
From: Outcome differences by sex in oncology clinical trials
Reason trial was missed | Number among 75 selected trials with enrollment ≥200 | Number among 147 trials with enrollment [175, 199] |
|---|---|---|
Paper exists but lacks any analysis by sex | 38 (51%) | 95 (65%) |
Paper has subgroup analysis by sex but no comparison | 17 (23%) | 10 (7%) |
No paper as of end of evaluation | 10 (13%) | 23 (16%) |
Paper has non-significant comparison missed by Trialtrove | 7 (9%) | 17 (12%) with 2/17 papers published after data freeze. |
Sex comparison in Trialtrove missed by our strategy, subsequently repaired | 1 (1%) | 0 (0%) |
Paper has a significant SOR or SE sex comparison in main document missed by Trialtrove | 1 (1%) | 2 (1%) |
