Fig. 5: Repair failures are not due to increased production of replication errors and do not increase with replicative age. | Nature Communications

Fig. 5: Repair failures are not due to increased production of replication errors and do not increase with replicative age.

From: Real-time monitoring of replication errors’ fate reveals the origin and dynamics of spontaneous mutations

Fig. 5

a Comparison of the rate of all YFP-MutL foci in (i) cells showing a long-lived focus and (ii) cells showing a short-lived focus (see dedicated subsection in Supplementary Note 1). The bars represent the average of three experiments (colored dots), with non-significant differences (two-sided Welch’s t-test, p-value = 0.69). b Repair efficiency, estimated as the ratio of the rate of long-lived YFP-MutL foci to the rate of all YFP-MutL foci, is plotted against the cells’ replicative age. Each color represents a different experiment. Dots are obtained by binning the cells by 10 generations. The horizontal black line is the average of all the data. No significant difference between the first and the last 10 generations (Barnard’s unconditional test, two-sided p-value = 0.64, Supplementary Table 10 and dedicated subsection in Supplementary Note 1). Source data are provided as a Source Data file.

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