Fig. 3: in vivo- and in vitro- chemoenzymatic synthesis of lactone 9.
From: A concise and scalable chemoenzymatic synthesis of prostaglandins
a Synthesis of lactone 9 based on an in vitro enzymatic desymmetrization and Johnson–Claisen reaction. b Matching NADPH regenerating system with CHMOrhodo1. c Scale-up of enzymatic Baeyer–Villiger reaction. THF tetrahydrofuran, NADP nicotinamide adenine dinucleotide phosphate.
