Fig. 4: Efficient synthesis of key intermediate 8 and ω-chains installation. | Nature Communications

Fig. 4: Efficient synthesis of key intermediate 8 and ω-chains installation.

From: A concise and scalable chemoenzymatic synthesis of prostaglandins

Fig. 4

a Screening the optimal condition for bromohydrin 8 formation reaction. b Screening the optimal condition for reductive coupling reaction of bromohydrin 8. c Bidentate ligands used in this work. d Reaction scope of reductive coupling reaction of bromohydrin 8. NBS N-bromosuccinimide, DMSO dimethyl sulfoxide, DMA dimethylacetamide, TSIM N-(trimethylsilyl)imidazole.

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