Fig. 3: Molecular mucosal changes in responders following fecal microbiota transplantation (FMT) differentiate them from non-responders cross-sectionally. | Nature Communications

Fig. 3: Molecular mucosal changes in responders following fecal microbiota transplantation (FMT) differentiate them from non-responders cross-sectionally.

From: Profiling the colonic mucosal response to fecal microbiota transplantation identifies a role for GBP5 in colitis in humans and mice

Fig. 3

A Principal coordinate analysis (PCO) of differentially expressed genes in responders (n = 78 genes). Bray-Curtis similarities were calculated on log(x + 1) transformed normalized counts of host genes. Inter-group differences were tested using One-Way ANOSIM, with one-tailed significance computed by permutation, and only pair-wise differences with Tx8Y are shown. Tx0N, non-responder baseline (pink); Tx0Y, responder baseline (light blue); Tx8N, non-responder post-FMT (purple); Tx8Y, responder post-FMT (gray). B Constrained ordination using Canonical Analysis of Principal coordinates (CAP). Classification of samples according to group is presented in the table. C Top three genes significantly (q < 0.05) correlated with PCO axis 2. PCO axis 2 was chosen because the majority of variation between responders and non-responders post-FMT was observed on that axis. Pearson correlations were performed, and p values were corrected for false discovery rate (q value) using the Benjamini–Hochberg method. Source data are provided as a Source Data file.

Back to article page