Fig. 4: Cross-ancestry fine mapping improves resolution between cohorts of EUR and EAS ancestry.
From: Genetic control of DNA methylation is largely shared across European and East Asian populations
a Box plot of size of 95% credible set presented for 6385 mQTL associations in EUR, EAS and cross-ancestry populations. Single ancestry fine mapping was performed using SuSiE and cross-ancestry using SuSiEx. The cross-ancestry fine mapping resulted in decreased mean credible set size compared to single ancestry fine mapping performed in samples of EUR and EAS ancestry due to leveraged differences in LD structures across ancestries. Median values are shown in each boxplot, the box denotes the interquartile range and whiskers denote the rest of the data distribution. b Fine mapping of DNAm probe cg09192572 demonstrates improved resolution by incorporating cross-ancestry information. Single ancestry fine mapping using SuSiE generated credible sets of 5 SNPs in EUR shown in red (left) and 3 SNPs in EAS shown in purple (right). The cross-ancestry credible set calculated using SuSiEx resulted in a refined set of 1 SNPs shown in blue. p values are from an inverse variance-weighted meta-analysis and are not corrected for multiple testing.
