Table 1 Cis-mQTL analysis identified 112,390 unique DNAm probes with significant mQTL across the five cohorts with within-ancestry meta-analysis increasing discovery mQTLs at 129,155 DNAm probes

From: Genetic control of DNA methylation is largely shared across European and East Asian populations

Ā 

Sample size

Number of DNAm probes with mQTL

Percentage of DNAm probes with mQTL

Median distance between DNAm probe and lead SNP (Q1ā€“Q3; Kb)

Cohort

Ā Ā Ā Ā 

SGPD

1659

89,328

22.1%

6.8 (1.2ā€“23.5)

LBC

1437

70,872

17.5%

5.2 (0.7ā€“19.8)

BSGS*

605*

24,147

6.0%

4.9 (0.7ā€“17.9)

CHNMND

651

66,491

16.4%

4.3 (0.7ā€“16.4)

THCH

1448

73,638

18.2%

9.1 (2.4ā€“28.1)

Ancestry

Ā Ā Ā Ā 

EUR

3701

113,976

28.2%

6.8 (1.2ā€“24.8)

EAS

2099

95,583

23.6%

7.5 (1.7ā€“24.7)

  1. Shown are the number of DNAm probes with significant mQTL detected in each cohort and each meta-analysed ancestry, alongside the median distance between the DNAm probe and lead SNP. Q1 and Q3 denote the first and third quartiles. A Bonferroni corrected, two-sided p value threshold of pā€‰<ā€‰10āˆ’10 was used to define significance at the cohort level from linear regression and mixed linear regression models, and at the ancestry level using inverse variance-weighted meta-analysis. *BSGS cohort includes related individuals from 177 families.
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