Fig. 1: CUPiD, an accurate tissue-of-origin classifier applicable to cfDNA.
From: A cfDNA methylation-based tissue-of-origin classifier for cancers of unknown primary
a Schematic of CUPiD development (DMR=Differentially Methylated Region). b Two-dimensional Uniform Manifold Approximation and Projection for Dimension Reduction (UMAP) using 22,179 DMRs selected by tumour class by class comparison, applied to 9,017 converted methylation arrays. Class labels superimposed over centroid of members of that class. c Per-class Receiver Operator Characteristic (ROC) curves for CUPiD, each using 276,108 mixture sets. Tissue-of-origin predictions for each mixture set are averaged over predictions made by those sub-classifiers not using that mixture set for training. Colours represent 30 individual classes as in Fig. 1b. Class abbreviations are defined in Table 1. Source Data are provided as a Source Data file.
