Fig. 1: Pressure stimulation activates TRAAK, TREK-1, and TREK-2 channels.
From: Tension activation of mechanosensitive two-pore domain K+ channels TRAAK, TREK-1, and TREK-2
A, C, E Macroscopic currents (upper) recorded at 0 mV in a tenfold [K+] gradient from a A TRAAK-, C TREK-1-, or E TREK-2-containing patch in response to a pressure step protocol (lower). B, D, F Normalized current–pressure relationships from B 12 TRAAK-, D 6 TREK-1-, or F 9 TREK-2-containing patches (from n = 5, 3, and 6 cells, respectively). Normalized current is defined as the peak current recorded during each pressure step (I) over the maximum current recorded for each patch (Imax). Data from each patch are shown as different-shaped points connected by a line.
