Fig. 4: Mammalian phyletic pattern of MHC gene families reveals a small MHC-I, relative to MHC-II, gene-family size in the NMR genome.
From: Evolution of T cells in the cancer-resistant naked mole-rat
A Phyletic pattern showing the numbers of genomically-encoded MHC-I and MHC-II annotated protein-coding and pseudo -genes, and unannotated putative pseudogenes, in 67 mammalian genomes (Methods), revealing the small numbers of MHC-I genes in the NMR genome relative to other mammalian genomes. The phylogeny is color-coded by orders, where the Rodentia order is further color-coded by suborder; (B) horizontal bar-chart showing the natural log (ln) ratio of the number of MHC-I genes scaled to the number of MHC-II genes. Negative and positive ratios are color-coded in shades of blue and red, respectively, according to their magnitude, emphasizing the low ratios in the genomes of NMR and the other hystricomorphs except for the guinea pig. Source data are provided as Source data file.
