Table 1 ISCU2-bound metal to ligand and sulfur to sulfur distances in various structures of free ISCU2 or core ISC complexes

Resolution

–

3.32 Å

3.32 Å

2.75 Å

3.20 Å

2.58 Å

2.49 Å

Reference

–

Boniecki (2017)¹⁵

Boniecki (2017)¹⁵

This work

Fox (2019)¹⁷

This work

This work

Organism

Mus musculus

Homo sapiens

Homo sapiens

Homo sapiens

Homo sapiens

Homo sapiens

Homo sapiens

PDB code

1WFZ

5WLW

5WLW

8PKA

6NZU

8PK9

8PK8

Structure

Zn-U

(Zn-NIAU)₂

(Zn 201.D)

(Zn-NIAU)₂

(Zn 201.H)

(Fe-NIAU)₂

(Zn-NIAUX)₂

(Fe-N^SIAU^SX)₂

(Fe-NIAU^SX)₂

C69

2.3^#

6.1

4.8

3.7

10.0

9.6

9.7

D71 OD1

3.5

3.1

2.9^#

2.1^#

2.3^#

2.1^#

2.0^#

D71 OD2

2.1^#

2.4^#

2.4^#

2.2^#

2.3^#

2.1^#

2.1^#

C95

2.3^#

2.8^#

2.9^#

2.3^#

2.8^a

2.4^#

2.3^#

H137 NE2

2.1^#

2.8^#

3.2

4.8

10.5

9.8

9.9

C138

3.6

3.9

3.9

4.7

2.9^#

2.3^#

2.3^#

C381 (NFS1)

–

2.9^#

2.8^#

2.4^#

12.3

2.3^#

20.9

Water

–

–

–

2.0^#

–

–

2.0^#

C381-C69

4.2

4.8

4.3

9.6

C381-C95

5.2

4.8

3.8

3.4

C381-C138

6.3

6.5

6.5

3.6