Fig. 8: AAV9-mediated circRNA-RBCK1 gene knockdown abolishes the effects of lovastatin in HFpEF mice. | Nature Communications

Fig. 8: AAV9-mediated circRNA-RBCK1 gene knockdown abolishes the effects of lovastatin in HFpEF mice.

From: Statins improve cardiac endothelial function to prevent heart failure with preserved ejection fraction through upregulating circRNA-RBCK1

Fig. 8

The protocols and experimental designs were described in Supplementary Fig. 10A. A–C Representative pulsed-wave Doppler (top) and tissue Doppler (bottom) tracings were shown in (A). The values of E/E′ in (B) and E/A in (C) were presented. D–F Ratio between wet and dry lung weight (LW) in (D), running distance during exercise exhaustion test in (E), and the ratio of heart weight to tibia length (HW/TL) in (F) were calculated. G and H Left ventricle wall was isolated to determine GTPCH1 mRNA by quantitative PCR and BH4 contents by HPLC. N = 11 (AAV9-NC alone), N = 12 (AAV9-NC + lovastatin), N = 13 (circRNA shRNA alone), N = 12 (circRNA shRNA + lovastatin. A one-way ANOVA followed by Scheffe tests was used to determine the P value in (B–H). Data are presented as mean ± SD. Source data are provided as a Source Data file.

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