Fig. 3: Viral distribution following ECTV infection and treatment at five dpi. | Nature Communications

Fig. 3: Viral distribution following ECTV infection and treatment at five dpi.

From: Synergistic effect of two human-like monoclonal antibodies confers protection against orthopoxvirus infection

Fig. 3: Viral distribution following ECTV infection and treatment at five dpi.

A BALB/c mice were divided into two groups (IVIS (A); red and IVIS (B); blue) infected with 140 PFU i.n. ECTV-Luc, treated with MV33 (200 µg), EV42 (200 µg), MV33 + EV42 (100 + 100 µg), VIGIV (VIG; 4 mg) or isotype control (BLN12; 200 µg) on day five p.i. (n  =  8) and imaged on days 6, 10 and 14 (IVIS (B) or on days 8 and 12 (IVIS (A); n = 4 for each treated group; red); n = 4 for each treated group; blue). Bioluminescent signal intensity range is shown below each column (color scale; photon/s/cm2/sr). Dagger represents dead mice. The Scheme was created with BioRender.com (full license). B Bioluminescent signal/noise intensity as total photon flux (photon/s/cm2/sr), was calculated by region of interest (ROI) analysis on the chest and abdomen cavity. Same ROI was used for all mice examined. Measurement data are expressed as mean ± standard error (SE). Source data are provided as a Source Data file.

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