Fig. 3: Compounds of structural group #4 inhibit C. elegans mitochondrial NADH:ubiquinone oxidoreductase (complex I) in vitro.
From: Identification of a family of species-selective complex I inhibitors as potential anthelmintics
a Chemical structures of the four molecules of structural group #4 (NPD10504, NPD3577, NPD6303, and NPD8790) and papaverine, a structurally related commercial analog. b Dose-response curves of papaverine and group #4 compounds against the in vitro complex I activity from wild-type C. elegans (N2) mitochondria. The half-maximal inhibitory concentrations or IC50 values estimated from fitted curves are displayed for each compound. c & d Dose-response curves for papaverine (c) and NPD8790 (d) against in vitro complex I activity from C. elegans, M. musculus heart, and B. taurus heart mitochondria. IC50 values estimated from fitted curves are displayed for each combination of compound and mitochondria. All data are the mean of at least three biological replicates; error bars represent SEM.
