Fig. 3: Structural characterization of R882-mutated DNMT3A.
From: Structure-guided functional suppression of AML-associated DNMT3A hotspot mutations
a Structural overlay between WT DNMT3A (green) and DNMT3AR882H/R676K (pink). The disordered TRDs in the external subunits are shown as dashed lines. b Structural comparison of the RD interface between WT DNMT3A and DNMT3AR882H/R676K, with residues involved in intermolecular interactions shown in stick representation. Hydrogen bonds are shown as dashed lines. c Close-up view of residues involved in H882-mediated interactions in DNMT3AR882H/R676K. The van der Waals radii of their sidechain atoms are depicted by dot representation. d Structural overlay between WT DNMT3A (green) and DNMT3AR882C/R676K (magenta). The disordered TRDs are shown as dashed lines. e Close-up view of residues involved in C882-mediated contacts in DNMT3AR882C/R676K. The van der Waals radii of their sidechain atoms are depicted by dot representation. Hydrogen bonds are shown as dashed lines, with distances labeled in unit of Å.
