Fig. 7: A model for the dynamic assembly of DNMT3A, WT or mutant.
From: Structure-guided functional suppression of AML-associated DNMT3A hotspot mutations
WT DNMT3A is dominated by the tetrameric assembly, whereas the R882H or R882C mutation shifts the equilibrium toward high-order oligomerization or even aggregation. Introducing the DNMT3B-converting mutation at the RD interface in part shifts the population of the assemblies back toward the tetramers.
