Fig. 2: Interactions between Asc-1 and 4F2hc during conformational change.
From: Cryo-EM structure of the human Asc-1 transporter complex
a Structural comparison between Asc-1-4F2hc adopting different conformations. When the substrate is bound to Asc-1, its state will change from inward open state to occluded state. The colored boxes correspond to detailed images in b, c and d. b The extracellular interface between Asc-1 and 4F2hc. c The intracellular interface. d The hydrophobic interactions between the transmembrane region of 4F2hc and TM4 of Asc-1. Dashed lines indicate possible H-bond interactions.
