Fig. 4: Functional implication of oxidised membrane proteins by BTP photocatalysis.
From: Oxidative photocatalysis on membranes triggers non-canonical pyroptosis
a Protein quality control (PQC) related proteins was highlighted on the volcano plot of membrane proteins by their functional categories. Oxidised proteins were defined by the strict criteria (P-value < 0.01, Fold Change > 4), based on the intensity of oxidative modifications of all amino acids excluding Gly, Ser, Thr, and O-Met ( + 16 Da). b The count and percentage of proteins satisfying the oxidation criteria. c Distribution of oxidised membrane proteins across cellular organelles. ‘Others’ include plasma membranes and unidentified locations. d Heatmap comparison of highlighted protein oxidation between experimental and control conditions. e String network of the strictly defined oxidised proteins (P < 0.01, FC > 4), filtered for high interaction confidence (0.9) illustrated with GO biological processes and GO enrichment scores. Node size reflects log2FC values, and disconnected nodes were excluded from the network. Key PQC-related processes were marked in blue. All P values were calculated for Student’s one-tailed t test. Source data are provided as a Source Data file.
