Fig. 4: Reconstitution of immune cell subsets at 24-months. | Nature Communications

Fig. 4: Reconstitution of immune cell subsets at 24-months.

From: Improvement of immune dysregulation in individuals with long COVID at 24-months following SARS-CoV-2 infection

Fig. 4

A Longitudinal plot showing changes in cell subset proportions overtime (3-, 8- and 24-months) in MC (left) and LC (right) (B) UMAP showing cellular composition single-cell RNAseq data; all (combined cells [45,988 cells]) then separated into LC (n = 10) and MC (n = 10) at 24-months. C Composition of cell subset frequencies between LC and MC with p values and false discovery rate (FDR). D UMAP assessing only naïve B and T cell subsets, with no clear difference between LC or MC. E Box and whiskers graph (median with IQR) showing interferon response scores (IRS) in innate cell subsets. Elevated IRS in CD14+ monocytes. F Exhaustion score in T cell subsets. Dots represent individual cells (outliers) for each subset with weighted scores (median with IQR). LC Long COVID, MC matched controls. Data shown as mean scores. p < 0.05 (*), < 0.0001(****) were considered significant. Data represent n = 10 biologically independent samples per group. Source data are provided as a Source Data file.

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